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Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors

There are several hereditary diseases that are a predisposition to early-onset tumors. These include syndromic conditions like neurofibromatosis 1 and 2, von Hippel-Lindau syndrome, Gorlin syndrome, multiple endocrine neoplasia, and familial adenomatous polyposis; and conditions which are usually no...

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Autores principales: Evans, D Gareth R, Ingham, Sarah Louise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735038/
https://www.ncbi.nlm.nih.gov/pubmed/23935382
http://dx.doi.org/10.2147/TACG.S35605
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author Evans, D Gareth R
Ingham, Sarah Louise
author_facet Evans, D Gareth R
Ingham, Sarah Louise
author_sort Evans, D Gareth R
collection PubMed
description There are several hereditary diseases that are a predisposition to early-onset tumors. These include syndromic conditions like neurofibromatosis 1 and 2, von Hippel-Lindau syndrome, Gorlin syndrome, multiple endocrine neoplasia, and familial adenomatous polyposis; and conditions which are usually not possible to diagnose clinically in a single individual, such as Lynch syndrome and BRCA1/2. Understanding of the mortality in hereditary cancer predisposing diseases is important for developing effective disease treatment programs. A number of studies have been undertaken to investigate the genetic predictors, prevalence and incidence, and treatment outcomes of these diseases; however, the majority examine only the most common of these diseases (eg, neurofibromatosis or BRCA), or look into postoperative survival. The mortality of individuals who are diagnosed with one of these hereditary diseases remains an area for investigation. This review is the first to attempt identification of studies investigating life expectancy in hereditary diseases which predispose to early-onset tumors.
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spelling pubmed-37350382013-08-09 Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors Evans, D Gareth R Ingham, Sarah Louise Appl Clin Genet Review There are several hereditary diseases that are a predisposition to early-onset tumors. These include syndromic conditions like neurofibromatosis 1 and 2, von Hippel-Lindau syndrome, Gorlin syndrome, multiple endocrine neoplasia, and familial adenomatous polyposis; and conditions which are usually not possible to diagnose clinically in a single individual, such as Lynch syndrome and BRCA1/2. Understanding of the mortality in hereditary cancer predisposing diseases is important for developing effective disease treatment programs. A number of studies have been undertaken to investigate the genetic predictors, prevalence and incidence, and treatment outcomes of these diseases; however, the majority examine only the most common of these diseases (eg, neurofibromatosis or BRCA), or look into postoperative survival. The mortality of individuals who are diagnosed with one of these hereditary diseases remains an area for investigation. This review is the first to attempt identification of studies investigating life expectancy in hereditary diseases which predispose to early-onset tumors. Dove Medical Press 2013-07-24 /pmc/articles/PMC3735038/ /pubmed/23935382 http://dx.doi.org/10.2147/TACG.S35605 Text en © 2013 Evans and Ingham, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Evans, D Gareth R
Ingham, Sarah Louise
Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
title Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
title_full Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
title_fullStr Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
title_full_unstemmed Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
title_short Reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
title_sort reduced life expectancy seen in hereditary diseases which predispose to early-onset tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735038/
https://www.ncbi.nlm.nih.gov/pubmed/23935382
http://dx.doi.org/10.2147/TACG.S35605
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