Clinically Relevant Mutant DNA Gyrase Alters Supercoiling, Changes the Transcriptome, and Confers Multidrug Resistance

Bacterial DNA is maintained in a supercoiled state controlled by the action of topoisomerases. Alterations in supercoiling affect fundamental cellular processes, including transcription. Here, we show that substitution at position 87 of GyrA of Salmonella influences sensitivity to antibiotics, inclu...

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Detalles Bibliográficos
Autores principales: Webber, Mark A., Ricci, Vito, Whitehead, Rebekah, Patel, Meha, Fookes, Maria, Ivens, Alasdair, Piddock, Laura J. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735185/
https://www.ncbi.nlm.nih.gov/pubmed/23882012
http://dx.doi.org/10.1128/mBio.00273-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735185/
https://www.ncbi.nlm.nih.gov/pubmed/23882012
http://dx.doi.org/10.1128/mBio.00273-13

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