Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib

Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma (HCC) in Child-Pugh A patients. We describe the case of a patient who presented with a large HCC in the left liver associated with portal vein thrombosis (PVT). After 9 months of sorafenib tre...

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Autores principales: Kermiche-Rahali, Sabrina, Di Fiore, Aude, Drieux, Fanny, Di Fiore, Frédéric, François, Arnaud, Scotté, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735470/
https://www.ncbi.nlm.nih.gov/pubmed/23914915
http://dx.doi.org/10.1186/1477-7819-11-171
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author Kermiche-Rahali, Sabrina
Di Fiore, Aude
Drieux, Fanny
Di Fiore, Frédéric
François, Arnaud
Scotté, Michel
author_facet Kermiche-Rahali, Sabrina
Di Fiore, Aude
Drieux, Fanny
Di Fiore, Frédéric
François, Arnaud
Scotté, Michel
author_sort Kermiche-Rahali, Sabrina
collection PubMed
description Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma (HCC) in Child-Pugh A patients. We describe the case of a patient who presented with a large HCC in the left liver associated with portal vein thrombosis (PVT). After 9 months of sorafenib treatment, reassessment showed that the tumors had decreased in size with recanalization of the portal vein. A lateral left hepatectomy was performed and pathology showed complete necrosis of the tumor. Sorafenib can downstage HCC in patients with cirrhosis allowing further surgical resection.
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spelling pubmed-37354702013-08-07 Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib Kermiche-Rahali, Sabrina Di Fiore, Aude Drieux, Fanny Di Fiore, Frédéric François, Arnaud Scotté, Michel World J Surg Oncol Case Report Sorafenib is a molecular-targeted therapy used in palliative treatment of advanced hepatocellular carcinoma (HCC) in Child-Pugh A patients. We describe the case of a patient who presented with a large HCC in the left liver associated with portal vein thrombosis (PVT). After 9 months of sorafenib treatment, reassessment showed that the tumors had decreased in size with recanalization of the portal vein. A lateral left hepatectomy was performed and pathology showed complete necrosis of the tumor. Sorafenib can downstage HCC in patients with cirrhosis allowing further surgical resection. BioMed Central 2013-08-02 /pmc/articles/PMC3735470/ /pubmed/23914915 http://dx.doi.org/10.1186/1477-7819-11-171 Text en Copyright ©2013 Kermiche-Rahali et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kermiche-Rahali, Sabrina
Di Fiore, Aude
Drieux, Fanny
Di Fiore, Frédéric
François, Arnaud
Scotté, Michel
Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
title Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
title_full Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
title_fullStr Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
title_full_unstemmed Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
title_short Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
title_sort complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735470/
https://www.ncbi.nlm.nih.gov/pubmed/23914915
http://dx.doi.org/10.1186/1477-7819-11-171
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