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Pharmacological Reversal of Histone Methylation Presensitizes Pancreatic Cancer Cells to Nucleoside Drugs: In Vitro Optimization and Novel Nanoparticle Delivery Studies

We evaluated the potential of an investigational histone methylation reversal agent, 3-deazaneplanocin A (DZNep), in improving the chemosensitivity of pancreatic cancer to nucleoside analogs (i.e., gemcitabine). DZNep brought delayed but selective cytotoxicity to pancreatic cancer cells without affe...

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Detalles Bibliográficos
Autores principales:	Hung, Sau Wai, Mody, Hardik, Marrache, Sean, Bhutia, Yangzom D., Davis, Franklin, Cho, Jong Hyun, Zastre, Jason, Dhar, Shanta, Chu, Chung K., Govindarajan, Rajgopal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735519/ https://www.ncbi.nlm.nih.gov/pubmed/23940717 http://dx.doi.org/10.1371/journal.pone.0071196

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