Functional Identification of Close Proximity Amino Acid Side Chains within the Transmembrane-Spanning Helixes of the P2X2 Receptor

The transition from the closed to open state greatly alters the intra- and inter-subunit interactions of the P2X receptor (P2XR). The interactions that occur in the transmembrane domain of the P2X2R remain unclear. We used substituted cysteine mutagenesis disulfide mapping to identify pairs of resid...

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Detalles Bibliográficos
Autores principales: Liang, Xin, Xu, Huijuan, Li, Caiyue, Yin, Shikui, Xu, Tingting, Liu, Jinsong, Li, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735612/
https://www.ncbi.nlm.nih.gov/pubmed/23936459
http://dx.doi.org/10.1371/journal.pone.0070629

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