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An implantable electrical stimulator used for peripheral nerve rehabilitation in rats

This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel cla...

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Autores principales: RUI, BIYU, GUO, SHANGCHUN, ZENG, BINGFANG, WANG, JINGWU, CHEN, XIN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735806/
https://www.ncbi.nlm.nih.gov/pubmed/23935712
http://dx.doi.org/10.3892/etm.2013.1110
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author RUI, BIYU
GUO, SHANGCHUN
ZENG, BINGFANG
WANG, JINGWU
CHEN, XIN
author_facet RUI, BIYU
GUO, SHANGCHUN
ZENG, BINGFANG
WANG, JINGWU
CHEN, XIN
author_sort RUI, BIYU
collection PubMed
description This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while the remaining twenty rats were assigned to the control group. At three and six weeks following the surgery, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MCV) were demonstrated to be significantly higher in the implantation group compared with the control group (P<0.05). Histological analysis, using hematoxylin and eosin (H&E) staining, showed the typical pathological atrophy, and an assessment of the nerve that had been crushed revealed distal axonal breakdown in the control group. These results suggest that the implantable electrical stimulator was effective, and was suitable for implantation in a Sprague-Dawley rat model.
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spelling pubmed-37358062013-08-09 An implantable electrical stimulator used for peripheral nerve rehabilitation in rats RUI, BIYU GUO, SHANGCHUN ZENG, BINGFANG WANG, JINGWU CHEN, XIN Exp Ther Med Articles This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while the remaining twenty rats were assigned to the control group. At three and six weeks following the surgery, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MCV) were demonstrated to be significantly higher in the implantation group compared with the control group (P<0.05). Histological analysis, using hematoxylin and eosin (H&E) staining, showed the typical pathological atrophy, and an assessment of the nerve that had been crushed revealed distal axonal breakdown in the control group. These results suggest that the implantable electrical stimulator was effective, and was suitable for implantation in a Sprague-Dawley rat model. D.A. Spandidos 2013-07 2013-05-13 /pmc/articles/PMC3735806/ /pubmed/23935712 http://dx.doi.org/10.3892/etm.2013.1110 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
RUI, BIYU
GUO, SHANGCHUN
ZENG, BINGFANG
WANG, JINGWU
CHEN, XIN
An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
title An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
title_full An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
title_fullStr An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
title_full_unstemmed An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
title_short An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
title_sort implantable electrical stimulator used for peripheral nerve rehabilitation in rats
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735806/
https://www.ncbi.nlm.nih.gov/pubmed/23935712
http://dx.doi.org/10.3892/etm.2013.1110
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