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An implantable electrical stimulator used for peripheral nerve rehabilitation in rats
This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel cla...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735806/ https://www.ncbi.nlm.nih.gov/pubmed/23935712 http://dx.doi.org/10.3892/etm.2013.1110 |
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author | RUI, BIYU GUO, SHANGCHUN ZENG, BINGFANG WANG, JINGWU CHEN, XIN |
author_facet | RUI, BIYU GUO, SHANGCHUN ZENG, BINGFANG WANG, JINGWU CHEN, XIN |
author_sort | RUI, BIYU |
collection | PubMed |
description | This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while the remaining twenty rats were assigned to the control group. At three and six weeks following the surgery, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MCV) were demonstrated to be significantly higher in the implantation group compared with the control group (P<0.05). Histological analysis, using hematoxylin and eosin (H&E) staining, showed the typical pathological atrophy, and an assessment of the nerve that had been crushed revealed distal axonal breakdown in the control group. These results suggest that the implantable electrical stimulator was effective, and was suitable for implantation in a Sprague-Dawley rat model. |
format | Online Article Text |
id | pubmed-3735806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-37358062013-08-09 An implantable electrical stimulator used for peripheral nerve rehabilitation in rats RUI, BIYU GUO, SHANGCHUN ZENG, BINGFANG WANG, JINGWU CHEN, XIN Exp Ther Med Articles This study evaluated an implantable electrical stimulator using a sciatic nerve injury animal model, and ethological, electrophysiological and histological assessments. Forty Sprague-Dawley rats were used in the study, and were subjected to crushing of the right sciatic nerve with a micro-vessel clamp. Electrical stimulators were implanted in twenty of the rats (the implantation group), while the remaining twenty rats were assigned to the control group. At three and six weeks following the surgery, the sciatic nerve function index (SFI) and the motor nerve conduction velocity (MCV) were demonstrated to be significantly higher in the implantation group compared with the control group (P<0.05). Histological analysis, using hematoxylin and eosin (H&E) staining, showed the typical pathological atrophy, and an assessment of the nerve that had been crushed revealed distal axonal breakdown in the control group. These results suggest that the implantable electrical stimulator was effective, and was suitable for implantation in a Sprague-Dawley rat model. D.A. Spandidos 2013-07 2013-05-13 /pmc/articles/PMC3735806/ /pubmed/23935712 http://dx.doi.org/10.3892/etm.2013.1110 Text en Copyright © 2013, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles RUI, BIYU GUO, SHANGCHUN ZENG, BINGFANG WANG, JINGWU CHEN, XIN An implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
title | An implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
title_full | An implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
title_fullStr | An implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
title_full_unstemmed | An implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
title_short | An implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
title_sort | implantable electrical stimulator used for peripheral nerve rehabilitation in rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735806/ https://www.ncbi.nlm.nih.gov/pubmed/23935712 http://dx.doi.org/10.3892/etm.2013.1110 |
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