Cargando…
Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer
BACKGROUND: Studies have demonstrated lower rates of breast cancer survival for Black versus White women. Factors implicated include later stages at diagnosis, differences in tumor biology, and lower compliance rates to adjuvant hormone therapy (AHT) among Black women with hormone sensitive breast c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736077/ https://www.ncbi.nlm.nih.gov/pubmed/23961419 http://dx.doi.org/10.1186/2193-1801-2-356 |
_version_ | 1782279737077399552 |
---|---|
author | Bhatta, Sumita S Hou, Ningqi Moton, Zakiya N Polite, Blase N Fleming, Gini F Olopade, Olufunmilayo I Huo, Dezheng Hong, Susan |
author_facet | Bhatta, Sumita S Hou, Ningqi Moton, Zakiya N Polite, Blase N Fleming, Gini F Olopade, Olufunmilayo I Huo, Dezheng Hong, Susan |
author_sort | Bhatta, Sumita S |
collection | PubMed |
description | BACKGROUND: Studies have demonstrated lower rates of breast cancer survival for Black versus White women. Factors implicated include later stages at diagnosis, differences in tumor biology, and lower compliance rates to adjuvant hormone therapy (AHT) among Black women with hormone sensitive breast cancer. We examined factors associated with compliance to AHT among Black and White women with invasive breast cancer. METHODS: Women with estrogen receptor positive (ER+), non-metastatic breast cancer were identified by the cancer registry at the University of Chicago Hospital and asked to complete a mail-in survey. Compliance was defined by self-reported adherence to AHT ≥80% at the time of the survey plus medical record verification of persistence (completion of 5 years of AHT). Logistic regression was used to determine factors associated with compliance to AHT. RESULTS: 197 (135 White and 62 Black) women were included in the analysis. 97.4% of patients reported adherence to therapy. 87.4% were found to be persistent to therapy. Overall compliance was 87.7% with no statistically significant racial difference seen (87.9% in White and 87.0% in Black, P = 0.87). For both Black and White women, compliance was strongly associated with both perceived importance of AHT (OR =2.1, 95% CI:1.21-3.68,P = 0.009) and the value placed on their doctor’s opinion about the importance of AHT (OR = 4.80, 95% CI: 2.03-11.4, P < 0.001). CONCLUSIONS: In our cohort of Black and White women, perceived importance of AHT and the degree to which they valued their doctor’s opinion correlated with overall compliance. This suggests that Black and White women consider similar factors in their decision to take AHT. |
format | Online Article Text |
id | pubmed-3736077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-37360772013-08-07 Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer Bhatta, Sumita S Hou, Ningqi Moton, Zakiya N Polite, Blase N Fleming, Gini F Olopade, Olufunmilayo I Huo, Dezheng Hong, Susan Springerplus Research BACKGROUND: Studies have demonstrated lower rates of breast cancer survival for Black versus White women. Factors implicated include later stages at diagnosis, differences in tumor biology, and lower compliance rates to adjuvant hormone therapy (AHT) among Black women with hormone sensitive breast cancer. We examined factors associated with compliance to AHT among Black and White women with invasive breast cancer. METHODS: Women with estrogen receptor positive (ER+), non-metastatic breast cancer were identified by the cancer registry at the University of Chicago Hospital and asked to complete a mail-in survey. Compliance was defined by self-reported adherence to AHT ≥80% at the time of the survey plus medical record verification of persistence (completion of 5 years of AHT). Logistic regression was used to determine factors associated with compliance to AHT. RESULTS: 197 (135 White and 62 Black) women were included in the analysis. 97.4% of patients reported adherence to therapy. 87.4% were found to be persistent to therapy. Overall compliance was 87.7% with no statistically significant racial difference seen (87.9% in White and 87.0% in Black, P = 0.87). For both Black and White women, compliance was strongly associated with both perceived importance of AHT (OR =2.1, 95% CI:1.21-3.68,P = 0.009) and the value placed on their doctor’s opinion about the importance of AHT (OR = 4.80, 95% CI: 2.03-11.4, P < 0.001). CONCLUSIONS: In our cohort of Black and White women, perceived importance of AHT and the degree to which they valued their doctor’s opinion correlated with overall compliance. This suggests that Black and White women consider similar factors in their decision to take AHT. Springer International Publishing 2013-07-30 /pmc/articles/PMC3736077/ /pubmed/23961419 http://dx.doi.org/10.1186/2193-1801-2-356 Text en © Bhatta et al.; licensee Springer. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Bhatta, Sumita S Hou, Ningqi Moton, Zakiya N Polite, Blase N Fleming, Gini F Olopade, Olufunmilayo I Huo, Dezheng Hong, Susan Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer |
title | Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer |
title_full | Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer |
title_fullStr | Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer |
title_full_unstemmed | Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer |
title_short | Factors associated with compliance to adjuvant hormone therapy in Black and White women with breast cancer |
title_sort | factors associated with compliance to adjuvant hormone therapy in black and white women with breast cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736077/ https://www.ncbi.nlm.nih.gov/pubmed/23961419 http://dx.doi.org/10.1186/2193-1801-2-356 |
work_keys_str_mv | AT bhattasumitas factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT houningqi factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT motonzakiyan factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT politeblasen factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT flemingginif factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT olopadeolufunmilayoi factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT huodezheng factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer AT hongsusan factorsassociatedwithcompliancetoadjuvanthormonetherapyinblackandwhitewomenwithbreastcancer |