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Structural basis of kynurenine 3-monooxygenase inhibition

Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (i.e. kynurenine pathway), leads to amelioration of Huntington’s disease-relevant phenotypes in yeast, fruit fly, and mouse models(1–5), as well as a mouse model of Alzheimer’s disease(3). KMO is...

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Detalles Bibliográficos
Autores principales:	Amaral, Marta, Levy, Colin, Heyes, Derren J., Lafite, Pierre, Outeiro, Tiago F., Giorgini, Flaviano, Leys, David, Scrutton, Nigel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736096/ https://www.ncbi.nlm.nih.gov/pubmed/23575632 http://dx.doi.org/10.1038/nature12039

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