Induction of antiviral genes by the tumor microenvironment confers resistance to virotherapy

Oncolytic viruses obliterate tumor cells in tissue culture but not against the same tumors in vivo. We report that macrophages can induce a powerfully protective antiviral state in ovarian and breast tumors, rendering them resistant to oncolytic virotherapy. These tumors have activated JAK/STAT path...

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Detalles Bibliográficos
Autores principales: Liu, Yu-Ping, Suksanpaisan, Lukkana, Steele, Michael B., Russell, Stephen J., Peng, Kah-Whye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736178/
https://www.ncbi.nlm.nih.gov/pubmed/23921465
http://dx.doi.org/10.1038/srep02375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736178/
https://www.ncbi.nlm.nih.gov/pubmed/23921465
http://dx.doi.org/10.1038/srep02375

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