Cargando…

Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea

The mangrove endophytic fungus Aspergillus terreus (No. GX7-3B) was cultivated in potato dextrose liquid medium, and one rare thiophene compound (1), together with anhydrojavanicin (2), 8-O-methylbostrycoidin (3), 8-O-methyljavanicin (4), botryosphaerone D (5), 6-ethyl-5-hydroxy-3,7-dimethoxynaphtho...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Chun-Mei, Liu, Shi-Xin, Huang, Cai-Huan, Pang, Ji-Yan, Lin, Yong-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736441/
https://www.ncbi.nlm.nih.gov/pubmed/23877026
http://dx.doi.org/10.3390/md11072616
_version_ 1782279758687502336
author Deng, Chun-Mei
Liu, Shi-Xin
Huang, Cai-Huan
Pang, Ji-Yan
Lin, Yong-Cheng
author_facet Deng, Chun-Mei
Liu, Shi-Xin
Huang, Cai-Huan
Pang, Ji-Yan
Lin, Yong-Cheng
author_sort Deng, Chun-Mei
collection PubMed
description The mangrove endophytic fungus Aspergillus terreus (No. GX7-3B) was cultivated in potato dextrose liquid medium, and one rare thiophene compound (1), together with anhydrojavanicin (2), 8-O-methylbostrycoidin (3), 8-O-methyljavanicin (4), botryosphaerone D (5), 6-ethyl-5-hydroxy-3,7-dimethoxynaphthoquinone (6), 3β,5α-dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (7), 3β,5α,14α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (8), NGA0187 (9) and beauvericin (10), were isolated. Their structures were elucidated by analysis of spectroscopic data. This is the first report of a natural origin for compound 6. Moreover, compounds 3, 4, 5, 7, 8 and 10 were obtained from marine microorganism for the first time. In the bioactive assays in vitro, compounds 2, 3, 9 and 10 displayed remarkable inhibiting actions against α-acetylcholinesterase (AChE) with IC(50) values 2.01, 6.71, 1.89, and 3.09 μM, respectively. Furthermore, in the cytotoxicity assays, compounds 7 and 10 exhibited strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC(50) values 4.98 and 2.02 (MCF-7), 1.95 and 0.82 (A549), 0.68 and 1.14 (Hela), and 1.50 and 1.10 μM (KB), respectively; compound 8 had weak inhibitory activities against these tumor cell lines; compounds 1, 2, 3, 4, 5, 6 and 9 exhibited no inhibitory activities against them.
format Online
Article
Text
id pubmed-3736441
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-37364412013-08-07 Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea Deng, Chun-Mei Liu, Shi-Xin Huang, Cai-Huan Pang, Ji-Yan Lin, Yong-Cheng Mar Drugs Article The mangrove endophytic fungus Aspergillus terreus (No. GX7-3B) was cultivated in potato dextrose liquid medium, and one rare thiophene compound (1), together with anhydrojavanicin (2), 8-O-methylbostrycoidin (3), 8-O-methyljavanicin (4), botryosphaerone D (5), 6-ethyl-5-hydroxy-3,7-dimethoxynaphthoquinone (6), 3β,5α-dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (7), 3β,5α,14α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (8), NGA0187 (9) and beauvericin (10), were isolated. Their structures were elucidated by analysis of spectroscopic data. This is the first report of a natural origin for compound 6. Moreover, compounds 3, 4, 5, 7, 8 and 10 were obtained from marine microorganism for the first time. In the bioactive assays in vitro, compounds 2, 3, 9 and 10 displayed remarkable inhibiting actions against α-acetylcholinesterase (AChE) with IC(50) values 2.01, 6.71, 1.89, and 3.09 μM, respectively. Furthermore, in the cytotoxicity assays, compounds 7 and 10 exhibited strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC(50) values 4.98 and 2.02 (MCF-7), 1.95 and 0.82 (A549), 0.68 and 1.14 (Hela), and 1.50 and 1.10 μM (KB), respectively; compound 8 had weak inhibitory activities against these tumor cell lines; compounds 1, 2, 3, 4, 5, 6 and 9 exhibited no inhibitory activities against them. MDPI 2013-07-19 /pmc/articles/PMC3736441/ /pubmed/23877026 http://dx.doi.org/10.3390/md11072616 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Deng, Chun-Mei
Liu, Shi-Xin
Huang, Cai-Huan
Pang, Ji-Yan
Lin, Yong-Cheng
Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea
title Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea
title_full Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea
title_fullStr Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea
title_full_unstemmed Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea
title_short Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea
title_sort secondary metabolites of a mangrove endophytic fungus aspergillus terreus (no. gx7-3b) from the south china sea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736441/
https://www.ncbi.nlm.nih.gov/pubmed/23877026
http://dx.doi.org/10.3390/md11072616
work_keys_str_mv AT dengchunmei secondarymetabolitesofamangroveendophyticfungusaspergillusterreusnogx73bfromthesouthchinasea
AT liushixin secondarymetabolitesofamangroveendophyticfungusaspergillusterreusnogx73bfromthesouthchinasea
AT huangcaihuan secondarymetabolitesofamangroveendophyticfungusaspergillusterreusnogx73bfromthesouthchinasea
AT pangjiyan secondarymetabolitesofamangroveendophyticfungusaspergillusterreusnogx73bfromthesouthchinasea
AT linyongcheng secondarymetabolitesofamangroveendophyticfungusaspergillusterreusnogx73bfromthesouthchinasea