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Pathophysiology of Vascular Remodeling in Hypertension
Vascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov's contribution. We then move to some basic concepts on the biomech...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736482/ https://www.ncbi.nlm.nih.gov/pubmed/23970958 http://dx.doi.org/10.1155/2013/808353 |
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author | Renna, Nicolás F. de las Heras, Natalia Miatello, Roberto M. |
author_facet | Renna, Nicolás F. de las Heras, Natalia Miatello, Roberto M. |
author_sort | Renna, Nicolás F. |
collection | PubMed |
description | Vascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov's contribution. We then move to some basic concepts on the biomechanics of blood vessels and explain the definitions proposed by Mulvany for specific forms of remodeling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodeled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodeling is described, again with emphasis on human data. Some details are given on the three mechanisms to date which point to remodeling resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension. |
format | Online Article Text |
id | pubmed-3736482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37364822013-08-22 Pathophysiology of Vascular Remodeling in Hypertension Renna, Nicolás F. de las Heras, Natalia Miatello, Roberto M. Int J Hypertens Review Article Vascular remodeling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Glagov's contribution. We then move to some basic concepts on the biomechanics of blood vessels and explain the definitions proposed by Mulvany for specific forms of remodeling, especially inward eutrophic and inward hypertrophic. The available evidence for the existence of remodeled resistance vessels in hypertension comes next, with relatively more weight given to human, in comparison with animal data. Mechanisms are discussed. The impact of antihypertensive drug treatment on remodeling is described, again with emphasis on human data. Some details are given on the three mechanisms to date which point to remodeling resistance arteries as an independent predictor of cardiovascular risk in hypertensive patients. We terminate by considering the potential role of remodeling in the pathogenesis of endorgan damage and in the perpetuation of hypertension. Hindawi Publishing Corporation 2013 2013-07-22 /pmc/articles/PMC3736482/ /pubmed/23970958 http://dx.doi.org/10.1155/2013/808353 Text en Copyright © 2013 Nicolás F. Renna et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Renna, Nicolás F. de las Heras, Natalia Miatello, Roberto M. Pathophysiology of Vascular Remodeling in Hypertension |
title | Pathophysiology of Vascular Remodeling in Hypertension |
title_full | Pathophysiology of Vascular Remodeling in Hypertension |
title_fullStr | Pathophysiology of Vascular Remodeling in Hypertension |
title_full_unstemmed | Pathophysiology of Vascular Remodeling in Hypertension |
title_short | Pathophysiology of Vascular Remodeling in Hypertension |
title_sort | pathophysiology of vascular remodeling in hypertension |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736482/ https://www.ncbi.nlm.nih.gov/pubmed/23970958 http://dx.doi.org/10.1155/2013/808353 |
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