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Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer

Colorectal cancer (CRC) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world. Curcumin is a traditional medicine used for treatment of a wide variety of tumors. However, antimetastasis mechanism of curcumin on CRC has not yet be...

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Autores principales: Chen, Chun-Chieh, Sureshbabul, Munisamy, Chen, Huei-Wen, Lin, Yu-Shuang, Lee, Jen-Yi, Hong, Qi-Sheng, Yang, Ya-Chien, Yu, Sung-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736531/
https://www.ncbi.nlm.nih.gov/pubmed/23970932
http://dx.doi.org/10.1155/2013/541695
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author Chen, Chun-Chieh
Sureshbabul, Munisamy
Chen, Huei-Wen
Lin, Yu-Shuang
Lee, Jen-Yi
Hong, Qi-Sheng
Yang, Ya-Chien
Yu, Sung-Liang
author_facet Chen, Chun-Chieh
Sureshbabul, Munisamy
Chen, Huei-Wen
Lin, Yu-Shuang
Lee, Jen-Yi
Hong, Qi-Sheng
Yang, Ya-Chien
Yu, Sung-Liang
author_sort Chen, Chun-Chieh
collection PubMed
description Colorectal cancer (CRC) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world. Curcumin is a traditional medicine used for treatment of a wide variety of tumors. However, antimetastasis mechanism of curcumin on CRC has not yet been completely investigated. Here, we explored the underlying molecular mechanisms of curcumin on metastasis of CRC cells in vitro and in vivo. Curcumin significantly inhibits cell migration, invasion, and colony formation in vitro and reduces tumor growth and liver metastasis in vivo. We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells. Curcumin inhibits focal adhesion kinase (FAK) phosphorylation and enhances the expressions of several extracellular matrix components which play a critical role in invasion and metastasis. Curcumin reduces CD24 expression in a dose-dependent manner in CRC cells. Moreover, E-cadherin expression is upregulated by curcumin and serves as an inhibitor of EMT. These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells.
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spelling pubmed-37365312013-08-22 Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer Chen, Chun-Chieh Sureshbabul, Munisamy Chen, Huei-Wen Lin, Yu-Shuang Lee, Jen-Yi Hong, Qi-Sheng Yang, Ya-Chien Yu, Sung-Liang Evid Based Complement Alternat Med Research Article Colorectal cancer (CRC) is a serious public health problem that results due to changes of diet and various environmental stress factors in the world. Curcumin is a traditional medicine used for treatment of a wide variety of tumors. However, antimetastasis mechanism of curcumin on CRC has not yet been completely investigated. Here, we explored the underlying molecular mechanisms of curcumin on metastasis of CRC cells in vitro and in vivo. Curcumin significantly inhibits cell migration, invasion, and colony formation in vitro and reduces tumor growth and liver metastasis in vivo. We found that curcumin suppresses Sp-1 transcriptional activity and Sp-1 regulated genes including ADEM10, calmodulin, EPHB2, HDAC4, and SEPP1 in CRC cells. Curcumin inhibits focal adhesion kinase (FAK) phosphorylation and enhances the expressions of several extracellular matrix components which play a critical role in invasion and metastasis. Curcumin reduces CD24 expression in a dose-dependent manner in CRC cells. Moreover, E-cadherin expression is upregulated by curcumin and serves as an inhibitor of EMT. These results suggest that curcumin executes its antimetastasis function through downregulation of Sp-1, FAK, and CD24 and by promoting E-cadherin expression in CRC cells. Hindawi Publishing Corporation 2013 2013-07-21 /pmc/articles/PMC3736531/ /pubmed/23970932 http://dx.doi.org/10.1155/2013/541695 Text en Copyright © 2013 Chun-Chieh Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Chun-Chieh
Sureshbabul, Munisamy
Chen, Huei-Wen
Lin, Yu-Shuang
Lee, Jen-Yi
Hong, Qi-Sheng
Yang, Ya-Chien
Yu, Sung-Liang
Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
title Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
title_full Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
title_fullStr Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
title_full_unstemmed Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
title_short Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer
title_sort curcumin suppresses metastasis via sp-1, fak inhibition, and e-cadherin upregulation in colorectal cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736531/
https://www.ncbi.nlm.nih.gov/pubmed/23970932
http://dx.doi.org/10.1155/2013/541695
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