Cargando…
Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitiv...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736548/ https://www.ncbi.nlm.nih.gov/pubmed/23970941 http://dx.doi.org/10.1155/2013/946298 |
_version_ | 1782279776374882304 |
---|---|
author | Bookheimer, Susan Y. Renner, Brian A. Ekstrom, Arne Li, Zhaoping Henning, Susanne M. Brown, Jesse A. Jones, Mike Moody, Teena Small, Gary W. |
author_facet | Bookheimer, Susan Y. Renner, Brian A. Ekstrom, Arne Li, Zhaoping Henning, Susanne M. Brown, Jesse A. Jones, Mike Moody, Teena Small, Gary W. |
author_sort | Bookheimer, Susan Y. |
collection | PubMed |
description | Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitive benefits of polyphenols, found abundantly in pomegranate juice. We performed a preliminary, placebo-controlled randomized trial of pomegranate juice in older subjects with age-associated memory complaints using memory testing and functional brain activation (fMRI) as outcome measures. Thirty-two subjects (28 completers) were randomly assigned to drink 8 ounces of either pomegranate juice or a flavor-matched placebo drink for 4 weeks. Subjects received memory testing, fMRI scans during cognitive tasks, and blood draws for peripheral biomarkers before and after the intervention. Investigators and subjects were all blind to group membership. After 4 weeks, only the pomegranate group showed a significant improvement in the Buschke selective reminding test of verbal memory and a significant increase in plasma trolox-equivalent antioxidant capacity (TEAC) and urolithin A-glucuronide. Furthermore, compared to the placebo group, the pomegranate group had increased fMRI activity during verbal and visual memory tasks. While preliminary, these results suggest a role for pomegranate juice in augmenting memory function through task-related increases in functional brain activity. |
format | Online Article Text |
id | pubmed-3736548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37365482013-08-22 Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints Bookheimer, Susan Y. Renner, Brian A. Ekstrom, Arne Li, Zhaoping Henning, Susanne M. Brown, Jesse A. Jones, Mike Moody, Teena Small, Gary W. Evid Based Complement Alternat Med Research Article Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitive benefits of polyphenols, found abundantly in pomegranate juice. We performed a preliminary, placebo-controlled randomized trial of pomegranate juice in older subjects with age-associated memory complaints using memory testing and functional brain activation (fMRI) as outcome measures. Thirty-two subjects (28 completers) were randomly assigned to drink 8 ounces of either pomegranate juice or a flavor-matched placebo drink for 4 weeks. Subjects received memory testing, fMRI scans during cognitive tasks, and blood draws for peripheral biomarkers before and after the intervention. Investigators and subjects were all blind to group membership. After 4 weeks, only the pomegranate group showed a significant improvement in the Buschke selective reminding test of verbal memory and a significant increase in plasma trolox-equivalent antioxidant capacity (TEAC) and urolithin A-glucuronide. Furthermore, compared to the placebo group, the pomegranate group had increased fMRI activity during verbal and visual memory tasks. While preliminary, these results suggest a role for pomegranate juice in augmenting memory function through task-related increases in functional brain activity. Hindawi Publishing Corporation 2013 2013-07-22 /pmc/articles/PMC3736548/ /pubmed/23970941 http://dx.doi.org/10.1155/2013/946298 Text en Copyright © 2013 Susan Y. Bookheimer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bookheimer, Susan Y. Renner, Brian A. Ekstrom, Arne Li, Zhaoping Henning, Susanne M. Brown, Jesse A. Jones, Mike Moody, Teena Small, Gary W. Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints |
title | Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints |
title_full | Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints |
title_fullStr | Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints |
title_full_unstemmed | Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints |
title_short | Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints |
title_sort | pomegranate juice augments memory and fmri activity in middle-aged and older adults with mild memory complaints |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736548/ https://www.ncbi.nlm.nih.gov/pubmed/23970941 http://dx.doi.org/10.1155/2013/946298 |
work_keys_str_mv | AT bookheimersusany pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT rennerbriana pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT ekstromarne pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT lizhaoping pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT henningsusannem pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT brownjessea pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT jonesmike pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT moodyteena pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints AT smallgaryw pomegranatejuiceaugmentsmemoryandfmriactivityinmiddleagedandolderadultswithmildmemorycomplaints |