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Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints

Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitiv...

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Autores principales: Bookheimer, Susan Y., Renner, Brian A., Ekstrom, Arne, Li, Zhaoping, Henning, Susanne M., Brown, Jesse A., Jones, Mike, Moody, Teena, Small, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736548/
https://www.ncbi.nlm.nih.gov/pubmed/23970941
http://dx.doi.org/10.1155/2013/946298
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author Bookheimer, Susan Y.
Renner, Brian A.
Ekstrom, Arne
Li, Zhaoping
Henning, Susanne M.
Brown, Jesse A.
Jones, Mike
Moody, Teena
Small, Gary W.
author_facet Bookheimer, Susan Y.
Renner, Brian A.
Ekstrom, Arne
Li, Zhaoping
Henning, Susanne M.
Brown, Jesse A.
Jones, Mike
Moody, Teena
Small, Gary W.
author_sort Bookheimer, Susan Y.
collection PubMed
description Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitive benefits of polyphenols, found abundantly in pomegranate juice. We performed a preliminary, placebo-controlled randomized trial of pomegranate juice in older subjects with age-associated memory complaints using memory testing and functional brain activation (fMRI) as outcome measures. Thirty-two subjects (28 completers) were randomly assigned to drink 8 ounces of either pomegranate juice or a flavor-matched placebo drink for 4 weeks. Subjects received memory testing, fMRI scans during cognitive tasks, and blood draws for peripheral biomarkers before and after the intervention. Investigators and subjects were all blind to group membership. After 4 weeks, only the pomegranate group showed a significant improvement in the Buschke selective reminding test of verbal memory and a significant increase in plasma trolox-equivalent antioxidant capacity (TEAC) and urolithin A-glucuronide. Furthermore, compared to the placebo group, the pomegranate group had increased fMRI activity during verbal and visual memory tasks. While preliminary, these results suggest a role for pomegranate juice in augmenting memory function through task-related increases in functional brain activity.
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spelling pubmed-37365482013-08-22 Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints Bookheimer, Susan Y. Renner, Brian A. Ekstrom, Arne Li, Zhaoping Henning, Susanne M. Brown, Jesse A. Jones, Mike Moody, Teena Small, Gary W. Evid Based Complement Alternat Med Research Article Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitive benefits of polyphenols, found abundantly in pomegranate juice. We performed a preliminary, placebo-controlled randomized trial of pomegranate juice in older subjects with age-associated memory complaints using memory testing and functional brain activation (fMRI) as outcome measures. Thirty-two subjects (28 completers) were randomly assigned to drink 8 ounces of either pomegranate juice or a flavor-matched placebo drink for 4 weeks. Subjects received memory testing, fMRI scans during cognitive tasks, and blood draws for peripheral biomarkers before and after the intervention. Investigators and subjects were all blind to group membership. After 4 weeks, only the pomegranate group showed a significant improvement in the Buschke selective reminding test of verbal memory and a significant increase in plasma trolox-equivalent antioxidant capacity (TEAC) and urolithin A-glucuronide. Furthermore, compared to the placebo group, the pomegranate group had increased fMRI activity during verbal and visual memory tasks. While preliminary, these results suggest a role for pomegranate juice in augmenting memory function through task-related increases in functional brain activity. Hindawi Publishing Corporation 2013 2013-07-22 /pmc/articles/PMC3736548/ /pubmed/23970941 http://dx.doi.org/10.1155/2013/946298 Text en Copyright © 2013 Susan Y. Bookheimer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bookheimer, Susan Y.
Renner, Brian A.
Ekstrom, Arne
Li, Zhaoping
Henning, Susanne M.
Brown, Jesse A.
Jones, Mike
Moody, Teena
Small, Gary W.
Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
title Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
title_full Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
title_fullStr Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
title_full_unstemmed Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
title_short Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
title_sort pomegranate juice augments memory and fmri activity in middle-aged and older adults with mild memory complaints
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736548/
https://www.ncbi.nlm.nih.gov/pubmed/23970941
http://dx.doi.org/10.1155/2013/946298
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