Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy

AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression. SUBJECTS AND METHODS: Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs. RESULTS: Serum Cu/Zn SOD...

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Detalles Bibliográficos
Autor principal: Russo, A.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2010
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736885/
https://www.ncbi.nlm.nih.gov/pubmed/23966790
http://dx.doi.org/10.4137/NMI.S5044
Descripción
Sumario:AIM: To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression. SUBJECTS AND METHODS: Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs. RESULTS: Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls. DISCUSSION: These results suggest an association between Cu/Zn SOD serum levels and clinical depression.

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