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Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain

BACKGROUND: The triallelic serotonin transporter gene linked polymorphic region (5-HTTLPR) has been associated with alterations in thermal pain perception. The primary aim of this study was to investigate the associations between heat pain (HP) perception and the triallelic 5-HTTLPR in a large cohor...

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Autores principales: Hooten, W Michael, Hartman, William R, Black, John Logan, Laures, Heidi J, Walker, Denise L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737051/
https://www.ncbi.nlm.nih.gov/pubmed/23895108
http://dx.doi.org/10.1186/1471-2350-14-78
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author Hooten, W Michael
Hartman, William R
Black, John Logan
Laures, Heidi J
Walker, Denise L
author_facet Hooten, W Michael
Hartman, William R
Black, John Logan
Laures, Heidi J
Walker, Denise L
author_sort Hooten, W Michael
collection PubMed
description BACKGROUND: The triallelic serotonin transporter gene linked polymorphic region (5-HTTLPR) has been associated with alterations in thermal pain perception. The primary aim of this study was to investigate the associations between heat pain (HP) perception and the triallelic 5-HTTLPR in a large cohort of adults with chronic pain. METHODS: The cohort included 277 adults with chronic pain who met inclusion criteria, and were consecutively admitted to an outpatient pain rehabilitation program from March 2009 through March 2010. Individuals were genotyped for the triallelic 5-HTTLPR (including rs25531) and categorized as high, intermediate, or low expressors of the serotonin transporter. Standardized measures of HP perception were obtained using a validated quantitative sensory test method of levels. RESULTS: The distribution of the high, intermediate, and low expressing genotypes was 61 (22%), 149 (54%) and 67 (24%), respectively. The Hardy-Weinberg P-value was 0.204 which indicated no departure from equilibrium. A significant effect of genotype was observed for values of HP threshold (P = 0.029). Individual group comparisons showed that values of HP threshold were significantly greater in the intermediate compared to the high expressing group (P = 0.009) but not the low expressing group (P > 0.1). In a multiple variable linear regression model, the intermediate group (P = 0.034) and male sex (P = 0.021) were associated with significantly greater values of HP 0.5, but no significant genotype-by-sex interaction effect was observed. CONCLUSIONS: In this study that involved adults with chronic pain, the intermediate triallelic 5-HTTLPR expressing group, but not the low expressing group, was associated with greater HP thresholds compared to the high expressing group.
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spelling pubmed-37370512013-08-08 Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain Hooten, W Michael Hartman, William R Black, John Logan Laures, Heidi J Walker, Denise L BMC Med Genet Research Article BACKGROUND: The triallelic serotonin transporter gene linked polymorphic region (5-HTTLPR) has been associated with alterations in thermal pain perception. The primary aim of this study was to investigate the associations between heat pain (HP) perception and the triallelic 5-HTTLPR in a large cohort of adults with chronic pain. METHODS: The cohort included 277 adults with chronic pain who met inclusion criteria, and were consecutively admitted to an outpatient pain rehabilitation program from March 2009 through March 2010. Individuals were genotyped for the triallelic 5-HTTLPR (including rs25531) and categorized as high, intermediate, or low expressors of the serotonin transporter. Standardized measures of HP perception were obtained using a validated quantitative sensory test method of levels. RESULTS: The distribution of the high, intermediate, and low expressing genotypes was 61 (22%), 149 (54%) and 67 (24%), respectively. The Hardy-Weinberg P-value was 0.204 which indicated no departure from equilibrium. A significant effect of genotype was observed for values of HP threshold (P = 0.029). Individual group comparisons showed that values of HP threshold were significantly greater in the intermediate compared to the high expressing group (P = 0.009) but not the low expressing group (P > 0.1). In a multiple variable linear regression model, the intermediate group (P = 0.034) and male sex (P = 0.021) were associated with significantly greater values of HP 0.5, but no significant genotype-by-sex interaction effect was observed. CONCLUSIONS: In this study that involved adults with chronic pain, the intermediate triallelic 5-HTTLPR expressing group, but not the low expressing group, was associated with greater HP thresholds compared to the high expressing group. BioMed Central 2013-07-30 /pmc/articles/PMC3737051/ /pubmed/23895108 http://dx.doi.org/10.1186/1471-2350-14-78 Text en Copyright © 2013 Hooten et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hooten, W Michael
Hartman, William R
Black, John Logan
Laures, Heidi J
Walker, Denise L
Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
title Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
title_full Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
title_fullStr Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
title_full_unstemmed Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
title_short Associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
title_sort associations between serotonin transporter gene polymorphisms and heat pain perception in adults with chronic pain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737051/
https://www.ncbi.nlm.nih.gov/pubmed/23895108
http://dx.doi.org/10.1186/1471-2350-14-78
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