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The Curcumin Analog EF24 Targets NF-κB and miRNA-21, and Has Potent Anticancer Activity In Vitro and In Vivo

EF24 is a curcumin analog that has improved anticancer activity over curcumin, but its therapeutic potential and mechanism of action is unknown, which is important to address as curcumin targets multiple signaling pathways. EF24 inhibits the NF-κB but not the JAK-STAT signaling pathway in DU145 huma...

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Detalles Bibliográficos
Autores principales: Yang, Chuan He, Yue, Junming, Sims, Michelle, Pfeffer, Lawrence M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737134/
https://www.ncbi.nlm.nih.gov/pubmed/23940701
http://dx.doi.org/10.1371/journal.pone.0071130