Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication

Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout...

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Detalles Bibliográficos
Autores principales: Kollmannsberger, Lorenz K., Gassen, Nils C., Bultmann, Andrea, Hartmann, Jakob, Weber, Peter, Schmidt, Mathias V., Rein, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737170/
https://www.ncbi.nlm.nih.gov/pubmed/23733890
http://dx.doi.org/10.1534/g3.113.006445
Descripción
Sumario:Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout mice.

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