Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication

Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout...

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Autores principales: Kollmannsberger, Lorenz K., Gassen, Nils C., Bultmann, Andrea, Hartmann, Jakob, Weber, Peter, Schmidt, Mathias V., Rein, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737170/
https://www.ncbi.nlm.nih.gov/pubmed/23733890
http://dx.doi.org/10.1534/g3.113.006445
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author Kollmannsberger, Lorenz K.
Gassen, Nils C.
Bultmann, Andrea
Hartmann, Jakob
Weber, Peter
Schmidt, Mathias V.
Rein, Theo
author_facet Kollmannsberger, Lorenz K.
Gassen, Nils C.
Bultmann, Andrea
Hartmann, Jakob
Weber, Peter
Schmidt, Mathias V.
Rein, Theo
author_sort Kollmannsberger, Lorenz K.
collection PubMed
description Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout mice.
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spelling pubmed-37371702013-08-08 Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication Kollmannsberger, Lorenz K. Gassen, Nils C. Bultmann, Andrea Hartmann, Jakob Weber, Peter Schmidt, Mathias V. Rein, Theo G3 (Bethesda) Investigations Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease. We found that these mice carry a gene duplication of glyoxylase-1, which explains why glyoxylase-1 levels are increased in the Fkbp5 knockout mice. Genetics Society of America 2013-08-01 /pmc/articles/PMC3737170/ /pubmed/23733890 http://dx.doi.org/10.1534/g3.113.006445 Text en Copyright © 2013 Kollmannsberger et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Investigations
Kollmannsberger, Lorenz K.
Gassen, Nils C.
Bultmann, Andrea
Hartmann, Jakob
Weber, Peter
Schmidt, Mathias V.
Rein, Theo
Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
title Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
title_full Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
title_fullStr Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
title_full_unstemmed Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
title_short Increased Glyoxalase-1 Levels in Fkbp5 Knockout Mice Caused by Glyoxalase-1 Gene Duplication
title_sort increased glyoxalase-1 levels in fkbp5 knockout mice caused by glyoxalase-1 gene duplication
topic Investigations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737170/
https://www.ncbi.nlm.nih.gov/pubmed/23733890
http://dx.doi.org/10.1534/g3.113.006445
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