Cargando…

Inhibition of PPARα Induces Cell Cycle Arrest and Apoptosis, and Synergizes with Glycolysis Inhibition in Kidney Cancer Cells

Renal cell carcinoma (RCC) is the sixth most common cancer in the US. While RCC is highly metastatic, there are few therapeutics options available for patients with metastatic RCC, and progression-free survival of patients even with the newest targeted therapeutics is only up to two years. Thus, nov...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abu Aboud, Omran, Wettersten, Hiromi I., Weiss, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737191/ https://www.ncbi.nlm.nih.gov/pubmed/23951092 http://dx.doi.org/10.1371/journal.pone.0071115

Ejemplares similares

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer
por: Trott, Josephine F., et al.
Publicado: (2016)

α‐Fetoprotein fragment synergizes with sorafenib to inhibit hepatoma cell growth and migration and promote the apoptosis
por: Wang, Qiujiao, et al.
Publicado: (2022)

Isoliensinine induces cervical cancer cell cycle arrest and apoptosis by inhibiting the AKT/GSK3α pathway
por: Li, Hong-Li, et al.
Publicado: (2022)

Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway
por: Wang, Gang, et al.
Publicado: (2016)

Specific Inhibition of the Nuclear Exporter Exportin-1 Attenuates Kidney Cancer Growth
por: Wettersten, Hiromi I., et al.
Publicado: (2014)

Evening Primrose Oil Enhances Tamoxifen’s Anticancer Activity against Breast Cancer Cells by Inducing Apoptosis, Inhibiting Angiogenesis, and Arresting the Cell Cycle
por: Abd-Alhaseeb, Mohammad M., et al.
Publicado: (2022)

Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells
por: Zhang, Lin, et al.
Publicado: (2016)

Diosmetin Inhibits Cell Proliferation, Induces Cell Apoptosis and Cell Cycle Arrest in Liver Cancer
por: Ma, Aiqing, et al.
Publicado: (2020)

PPARγ and PPARα synergize to induce robust browning of white fat in vivo
por: Kroon, Tobias, et al.
Publicado: (2020)

Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
por: Feng, Jiao, et al.
Publicado: (2020)

Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest
por: ZHANG, YUSONG, et al.
Publicado: (2014)

Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis
por: Wang, Lintao, et al.
Publicado: (2015)

Wogonin inhibits the proliferation of myelodysplastic syndrome cells through the induction of cell cycle arrest and apoptosis
por: LU, HUIXIA, et al.
Publicado: (2015)

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells
por: Thinon, Emmanuelle, et al.
Publicado: (2016)

Esculetin Inhibits the Survival of Human Prostate Cancer Cells by Inducing Apoptosis and Arresting the Cell Cycle
por: Turkekul, Kader, et al.
Publicado: (2018)

Inhibition of tumor cell growth by adenine is mediated by apoptosis induction and cell cycle S phase arrest
por: Han, Ming, et al.
Publicado: (2017)

Dimethylfumarate Inhibits Colorectal Carcinoma Cell Proliferation: Evidence for Cell Cycle Arrest, Apoptosis and Autophagy
por: Kaluzki, Irina, et al.
Publicado: (2019)

Glycyrrhizic Acid Inhibits Proliferation of Gastric Cancer Cells by Inducing Cell Cycle Arrest and Apoptosis
por: Wang, Hao, et al.
Publicado: (2020)

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing
por: Tesori, Valentina, et al.
Publicado: (2015)

Specific Thiazolidinediones Inhibit Ovarian Cancer Cell Line Proliferation and Cause Cell Cycle Arrest in a PPARγ Independent Manner
por: Al-Alem, Linah, et al.
Publicado: (2011)

Inhibition of AMPK/PFKFB3 mediated glycolysis synergizes with penfluridol to suppress gallbladder cancer growth
por: Hu, Jiahao, et al.
Publicado: (2022)

ZHX1 Inhibits Gastric Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
por: Ma, Xingjie, et al.
Publicado: (2016)

Astaxanthin Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest of Mice H22 Hepatoma Cells
por: Shao, Yiye, et al.
Publicado: (2016)

CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and apoptosis
por: Cai, Bing, et al.
Publicado: (2017)

Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells
por: Hu, Qiang, et al.
Publicado: (2017)

Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest
por: Jiang, Xia-sen, et al.
Publicado: (2020)

Effects of PPARα inhibition in head and neck paraganglioma cells
por: Florio, Rosalba, et al.
Publicado: (2017)

Flubendazole inhibits glioma proliferation by G2/M cell cycle arrest and pro-apoptosis
por: Zhou, Xumin, et al.
Publicado: (2018)

Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis
por: Gao, Xin, et al.
Publicado: (2019)

CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma
por: Zhou, Yan, et al.
Publicado: (2021)

Translating Metabolic Reprogramming into New Targets for Kidney Cancer
por: Abu Aboud, Omran, et al.
Publicado: (2017)

Gambogenic acid inhibits the proliferation of small-cell lung cancer cells by arresting the cell cycle and inducing apoptosis
por: Huang, Tingting, et al.
Publicado: (2019)

Inhibition of DEK Enhances Doxorubicin-Induced Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia Cells
por: Tian, Xiaoxue, et al.
Publicado: (2022)

Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis
por: Shen, Dexin, et al.
Publicado: (2023)

α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell
por: Kwak, Hyun-Ho, et al.
Publicado: (2016)

Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis
por: Kuang, Ye, et al.
Publicado: (2018)

Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure
por: He, Le, et al.
Publicado: (2019)

SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis
por: Otsubo, T, et al.
Publicado: (2008)

Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells
por: Mern, D S, et al.
Publicado: (2010)

CMTM3 Inhibits Human Testicular Cancer Cell Growth through Inducing Cell-Cycle Arrest and Apoptosis
por: Li, Zesong, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fvphhu8go6lpocknhcs6a2thq6