CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli

Prokaryotes immunize themselves against transmissible genetic elements by the integration (acquisition) in clustered regularly interspaced short palindromic repeats (CRISPR) loci of spacers homologous to invader nucleic acids, defined as protospacers. Following acquisition, mono-spacer CRISPR RNAs (...

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Detalles Bibliográficos
Autores principales: Díez-Villaseñor, César, Guzmán, Noemí M., Almendros, Cristóbal, García-Martínez, Jesús, Mojica, Francisco J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737337/
https://www.ncbi.nlm.nih.gov/pubmed/23445770
http://dx.doi.org/10.4161/rna.24023

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