Arginine insertion and loss of N-linked glycosylation site in HIV-1 envelope V3 region confer CXCR4-tropism

The third variable region (V3) of HIV-1 envelope glycoprotein gp120 plays a key role in determination of viral coreceptor usage (tropism). However, which combinations of mutations in V3 confer a tropism shift is still unclear. A unique pattern of mutations in antiretroviral therapy-naive HIV-1 patie...

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Detalles Bibliográficos
Autores principales: Tsuchiya, Kiyoto, Ode, Hirotaka, Hayashida, Tsunefusa, Kakizawa, Junko, Sato, Hironori, Oka, Shinichi, Gatanaga, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737504/
https://www.ncbi.nlm.nih.gov/pubmed/23925152
http://dx.doi.org/10.1038/srep02389

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