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Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish
Customized TALENs and Cas9/gRNAs have been used for targeted mutagenesis in zebrafish to induce indels into protein-coding genes. However, indels are usually not sufficient to disrupt the function of non-coding genes, gene clusters or regulatory sequences, whereas large genomic deletions or inversio...
Autores principales: | Xiao, An, Wang, Zhanxiang, Hu, Yingying, Wu, Yingdan, Luo, Zhou, Yang, Zhipeng, Zu, Yao, Li, Wenyuan, Huang, Peng, Tong, Xiangjun, Zhu, Zuoyan, Lin, Shuo, Zhang, Bo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737551/ https://www.ncbi.nlm.nih.gov/pubmed/23748566 http://dx.doi.org/10.1093/nar/gkt464 |
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