Structural insights into the targeting of mRNA GU-rich elements by the three RRMs of CELF1

The CUG-BP, Elav-like family (CELF) of RNA-binding proteins control gene expression at a number of different levels by regulating pre-mRNA splicing, deadenylation and mRNA stability. We present structural insights into the binding selectivity of CELF member 1 (CELF1) for GU-rich mRNA target sequence...

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Detalles Bibliográficos
Autores principales: Edwards, John M., Long, Jed, de Moor, Cornelia H., Emsley, Jonas, Searle, Mark S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737555/
https://www.ncbi.nlm.nih.gov/pubmed/23748565
http://dx.doi.org/10.1093/nar/gkt470

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