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UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability

Although many genotoxic treatments upregulate the cyclin kinase inhibitor p21, agents such as UV irradiation trigger p21 degradation. This suggests that p21 blocks a process relevant for the cellular response to UV. Here, we show that forced p21 stabilization after UV strongly impairs damaged-DNA re...

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Detalles Bibliográficos
Autores principales:	Mansilla, Sabrina F., Soria, Gastón, Vallerga, María Belén, Habif, Martín, Martínez-López, Wilner, Prives, Carol, Gottifredi, Vanesa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737556/ https://www.ncbi.nlm.nih.gov/pubmed/23723248 http://dx.doi.org/10.1093/nar/gkt475

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