Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery. Because cells have many different RS, usually one for each amino acid, identification of the specific enzyme targeted by a new natural or synth...

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Detalles Bibliográficos
Autores principales: Orelle, Cédric, Szal, Teresa, Klepacki, Dorota, Shaw, Karen J., Vázquez-Laslop, Nora, Mankin, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737564/
https://www.ncbi.nlm.nih.gov/pubmed/23761439
http://dx.doi.org/10.1093/nar/gkt526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737564/
https://www.ncbi.nlm.nih.gov/pubmed/23761439
http://dx.doi.org/10.1093/nar/gkt526

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