Cargando…
Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition
Aminoacyl-transfer RNA (tRNA) synthetases (RS) are essential components of the cellular translation machinery and can be exploited for antibiotic discovery. Because cells have many different RS, usually one for each amino acid, identification of the specific enzyme targeted by a new natural or synth...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737564/ https://www.ncbi.nlm.nih.gov/pubmed/23761439 http://dx.doi.org/10.1093/nar/gkt526 |