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Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms

[Image: see text] Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nuc...

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Detalles Bibliográficos
Autores principales: Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737597/
https://www.ncbi.nlm.nih.gov/pubmed/23865422
http://dx.doi.org/10.1021/bi4008758
Descripción
Sumario:[Image: see text] Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nucleotide-binding domain (NBD2) was involved in binding of bithiazole correctors. Here, we show that bithiazole correctors could also rescue CFTR mutants that lacked NBD2. These results suggest that bithiazoles rescue CFTR mutants by two different mechanisms.