Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms

[Image: see text] Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nuc...

Descripción completa

Detalles Bibliográficos
Autores principales: Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737597/
https://www.ncbi.nlm.nih.gov/pubmed/23865422
http://dx.doi.org/10.1021/bi4008758
_version_ 1782279882080780288
author Loo, Tip W.
Bartlett, M. Claire
Clarke, David M.
author_facet Loo, Tip W.
Bartlett, M. Claire
Clarke, David M.
author_sort Loo, Tip W.
collection PubMed
description [Image: see text] Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nucleotide-binding domain (NBD2) was involved in binding of bithiazole correctors. Here, we show that bithiazole correctors could also rescue CFTR mutants that lacked NBD2. These results suggest that bithiazoles rescue CFTR mutants by two different mechanisms.
format Online
Article
Text
id pubmed-3737597
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-37375972013-08-08 Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms Loo, Tip W. Bartlett, M. Claire Clarke, David M. Biochemistry [Image: see text] Better correctors are needed to repair cystic fibrosis transmembrane conductance regulator (CFTR) processing mutants that cause cystic fibrosis. Determining where the correctors bind to CFTR would aid in the development of new correctors. A recent study reported that the second nucleotide-binding domain (NBD2) was involved in binding of bithiazole correctors. Here, we show that bithiazole correctors could also rescue CFTR mutants that lacked NBD2. These results suggest that bithiazoles rescue CFTR mutants by two different mechanisms. American Chemical Society 2013-07-18 2013-08-06 /pmc/articles/PMC3737597/ /pubmed/23865422 http://dx.doi.org/10.1021/bi4008758 Text en Copyright © 2013 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Loo, Tip W.
Bartlett, M. Claire
Clarke, David M.
Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
title Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
title_full Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
title_fullStr Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
title_full_unstemmed Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
title_short Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms
title_sort bithiazole correctors rescue cftr mutants by two different mechanisms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737597/
https://www.ncbi.nlm.nih.gov/pubmed/23865422
http://dx.doi.org/10.1021/bi4008758
work_keys_str_mv AT lootipw bithiazolecorrectorsrescuecftrmutantsbytwodifferentmechanisms
AT bartlettmclaire bithiazolecorrectorsrescuecftrmutantsbytwodifferentmechanisms
AT clarkedavidm bithiazolecorrectorsrescuecftrmutantsbytwodifferentmechanisms

Ejemplares similares