Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model

BACKGROUND: Dysregulation of the Notch pathway has been identified to play an important role in the development and progression of colorectal cancer (CRC). In this study, we used a patient-derived CRC explant model to investigate the efficacy of the clinical γ-secretase inhibitor (GSI) PF-03084014....

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Detalles Bibliográficos
Autores principales: Arcaroli, J J, Quackenbush, K S, Purkey, A, Powell, R W, Pitts, T M, Bagby, S, Tan, A C, Cross, B, McPhillips, K, Song, E-K, Tai, W M, Winn, R A, Bikkavilli, K, VanScoyk, M, Eckhardt, S G, Messersmith, W A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738122/
https://www.ncbi.nlm.nih.gov/pubmed/23868008
http://dx.doi.org/10.1038/bjc.2013.361

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