Interleukin-28B polymorphisms and hepatitis C virus clearance

In 2009, several independent studies revealed a strong association between genetic variation in the interleukin-28B (IL28B) locus and the outcome of treatment for chronic infection with hepatitis C virus (HCV). Hundreds of studies followed, and a recent meta-analysis reports more precise odds ratios...

Descripción completa

Detalles Bibliográficos
Autores principales: Chayama, Kazuaki, Hayes, C Nelson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738156/
https://www.ncbi.nlm.nih.gov/pubmed/24533893
http://dx.doi.org/10.1186/gm410
_version_ 1782476814557380608
author Chayama, Kazuaki
Hayes, C Nelson
author_facet Chayama, Kazuaki
Hayes, C Nelson
author_sort Chayama, Kazuaki
collection PubMed
description In 2009, several independent studies revealed a strong association between genetic variation in the interleukin-28B (IL28B) locus and the outcome of treatment for chronic infection with hepatitis C virus (HCV). Hundreds of studies followed, and a recent meta-analysis reports more precise odds ratios than previously published for associations between commonly reported IL28B polymorphisms and spontaneous HCV clearance or treatment outcome. These results should facilitate the interpretation of IL28B genotyping as part of personalized treatment approaches.
format Online
Article
Text
id pubmed-3738156
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-37381562013-08-09 Interleukin-28B polymorphisms and hepatitis C virus clearance Chayama, Kazuaki Hayes, C Nelson Genome Med Research Highlight In 2009, several independent studies revealed a strong association between genetic variation in the interleukin-28B (IL28B) locus and the outcome of treatment for chronic infection with hepatitis C virus (HCV). Hundreds of studies followed, and a recent meta-analysis reports more precise odds ratios than previously published for associations between commonly reported IL28B polymorphisms and spontaneous HCV clearance or treatment outcome. These results should facilitate the interpretation of IL28B genotyping as part of personalized treatment approaches. BioMed Central 2013-01-29 /pmc/articles/PMC3738156/ /pubmed/24533893 http://dx.doi.org/10.1186/gm410 Text en Copyright © 2013 BioMed Central Ltd
spellingShingle Research Highlight
Chayama, Kazuaki
Hayes, C Nelson
Interleukin-28B polymorphisms and hepatitis C virus clearance
title Interleukin-28B polymorphisms and hepatitis C virus clearance
title_full Interleukin-28B polymorphisms and hepatitis C virus clearance
title_fullStr Interleukin-28B polymorphisms and hepatitis C virus clearance
title_full_unstemmed Interleukin-28B polymorphisms and hepatitis C virus clearance
title_short Interleukin-28B polymorphisms and hepatitis C virus clearance
title_sort interleukin-28b polymorphisms and hepatitis c virus clearance
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738156/
https://www.ncbi.nlm.nih.gov/pubmed/24533893
http://dx.doi.org/10.1186/gm410
work_keys_str_mv AT chayamakazuaki interleukin28bpolymorphismsandhepatitiscvirusclearance
AT hayescnelson interleukin28bpolymorphismsandhepatitiscvirusclearance

Ejemplares similares