Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations

Systemic lupus erythematosus (SLE) is an autoimmune disease with known genetic, epigenetic, and environmental risk factors. To assess the role of DNA methylation in SLE, we collected CD4+ T-cells, CD19+ B-cells, and CD14+ monocytes from 49 SLE patients and 58 controls, and performed genome-wide DNA...

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Detalles Bibliográficos
Autores principales: Absher, Devin M., Li, Xinrui, Waite, Lindsay L., Gibson, Andrew, Roberts, Kevin, Edberg, Jeffrey, Chatham, W. Winn, Kimberly, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738443/
https://www.ncbi.nlm.nih.gov/pubmed/23950730
http://dx.doi.org/10.1371/journal.pgen.1003678

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