Cargando…

Innate Immune Responses and Antioxidant/Oxidant Imbalance Are Major Determinants of Human Chagas Disease

BACKGROUND: We investigated the pathological and diagnostic role of selected markers of inflammation, oxidant/antioxidant status, and cellular injury in human Chagas disease. METHODS: Seropositive/chagasic subjects characterized as clinically-symptomatic or clinically-asymptomatic (n = 116), seroneg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dhiman, Monisha, Coronado, Yun A., Vallejo, Cecilia K., Petersen, John R., Ejilemele, Adetoun, Nuñez, Sonia, Zago, Maria Paola, Spratt, Heidi, Garg, Nisha Jain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738450/ https://www.ncbi.nlm.nih.gov/pubmed/23951383 http://dx.doi.org/10.1371/journal.pntd.0002364

Ejemplares similares

Cardiac-Oxidized Antigens Are Targets of Immune Recognition by Antibodies and Potential Molecular Determinants in Chagas Disease Pathogenesis
por: Dhiman, Monisha, et al.
Publicado: (2012)

Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease
por: Gupta, Shivali, et al.
Publicado: (2013)

MnSOD(tg) Mice Control Myocardial Inflammatory and Oxidative Stress and Remodeling Responses Elicited in Chronic Chagas Disease
por: Dhiman, Monisha, et al.
Publicado: (2013)

Potential Utility of Protein Targets of Cysteine-S-Nitrosylation in Identifying Clinical Disease Status in Human Chagas Disease
por: Zago, Maria Paola, et al.
Publicado: (2019)

Changes in Proteome Profile of Peripheral Blood Mononuclear Cells in Chronic Chagas Disease
por: Garg, Nisha Jain, et al.
Publicado: (2016)

Onchocerca volvulus Mimicking Metastatic Breast Carcinoma
por: Nava, Victor E., et al.
Publicado: (2020)

P47(phox−/−) Mice Are Compromised in Expansion and Activation of CD8(+) T Cells and Susceptible to Trypanosoma cruzi Infection
por: Dhiman, Monisha, et al.
Publicado: (2014)

Oxidative Stress in Chagas Disease
por: Gupta, Shivali, et al.
Publicado: (2009)

Prognostic Performance of Peripheral Blood Biomarkers in Identifying Seropositive Individuals at Risk of Developing Clinically Symptomatic Chagas Cardiomyopathy
por: Choudhuri, Subhadip, et al.
Publicado: (2021)

Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models
por: Wan, Xianxiu, et al.
Publicado: (2021)

Platelets, Macrophages, and Thromboinflammation in Chagas Disease
por: Choudhuri, Subhadip, et al.
Publicado: (2022)

Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease
por: Wen, Jake J., et al.
Publicado: (2018)

Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease
por: Sánchez-Villamil, Juana P., et al.
Publicado: (2020)

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease
por: Choudhuri, Subhadip, et al.
Publicado: (2020)

PARP1 depletion improves mitochondrial and heart function in Chagas disease: Effects on POLG dependent mtDNA maintenance
por: Wen, Jake Jianjun, et al.
Publicado: (2018)

Trypanosoma cruzi Induces the PARP1/AP-1 Pathway for Upregulation of Metalloproteinases and Transforming Growth Factor β in Macrophages: Role in Cardiac Fibroblast Differentiation and Fibrosis in Chagas Disease
por: Choudhuri, Subhadip, et al.
Publicado: (2020)

Imbalance of Innate and Adaptive Immunity in Esophageal Achalasia
por: Yao, Lu, et al.
Publicado: (2023)

S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure
por: Koo, Sue-jie, et al.
Publicado: (2016)

Therapeutic Efficacy of a Subunit Vaccine in Controlling Chronic Trypanosoma cruzi Infection and Chagas Disease Is Enhanced by Glutathione Peroxidase Over-Expression
por: Gupta, Shivali, et al.
Publicado: (2015)

Autoinflammatory Diseases and Cytokine Storms—Imbalances of Innate and Adaptative Immunity
por: Marcuzzi, Annalisa, et al.
Publicado: (2021)

Dysregulation and imbalance of innate and adaptive immunity are involved in the cardiomyopathy progression
por: He, Bin, et al.
Publicado: (2022)

Origin of Monocytes/Macrophages Contributing to Chronic Inflammation in Chagas Disease: SIRT1 Inhibition of FAK-NFκB-Dependent Proliferation and Proinflammatory Activation of Macrophages
por: Wan, Xianxiu, et al.
Publicado: (2019)

Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection
por: Lokugamage, Nandadeva, et al.
Publicado: (2020)

Imbalance of Circulating Innate Lymphoid Cell Subpopulations in Patients With Septic Shock
por: Carvelli, Julien, et al.
Publicado: (2019)

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity
por: Sprenger, Hans-Georg, et al.
Publicado: (2021)

Defects of mtDNA Replication Impaired Mitochondrial Biogenesis During Trypanosoma cruzi Infection in Human Cardiomyocytes and Chagasic Patients: The Role of Nrf1/2 and Antioxidant Response
por: Wan, Xianxiu, et al.
Publicado: (2012)

Innate and Adaptive Immunity Imbalance With Severe COVID-19 Pneumonia in Children and Adults
por: Shokati Eshkiki, Zahra, et al.
Publicado: (2021)

Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease
por: Santos-Miranda, Artur, et al.
Publicado: (2020)

Allostatic Load and Effort-Reward Imbalance: Associations over the Working-Career
por: Coronado, José Ignacio Cuitún, et al.
Publicado: (2018)

SIRT1-PGC1α-NFκB Pathway of Oxidative and Inflammatory Stress during Trypanosoma cruzi Infection: Benefits of SIRT1-Targeted Therapy in Improving Heart Function in Chagas Disease
por: Wan, Xianxiu, et al.
Publicado: (2016)

Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease
por: Lokugamage, Nandadeva, et al.
Publicado: (2021)

Correction: Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease
por: Santos-Miranda, Artur, et al.
Publicado: (2020)

Shared neuroimmune and oxidative pathways underpinning Chagas disease and major depressive disorder
por: Duarte-Silva, Eduardo, et al.
Publicado: (2020)

Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi
por: Mesías, Andrea C., et al.
Publicado: (2019)

Increased Activity Imbalance in Fronto-Subcortical Circuits in Adolescents with Major Depression
por: Jiao, Qing, et al.
Publicado: (2011)

Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways
por: Frade, Amanda Farage, et al.
Publicado: (2013)

Antioxidant effect of Morus nigra on Chagas disease progression
por: Montenote, Michelly Cristina, et al.
Publicado: (2017)

Chagas Disease
por: Tustin, Aaron W., et al.
Publicado: (2016)

Imbalance of Th17, Treg, and helper innate lymphoid cell in the peripheral blood of patients with rheumatoid arthritis
por: Wang, Ting, et al.
Publicado: (2022)

Impaired frequencies and function of platelets and tissue remodeling in chronic Chagas disease
por: Pengue, Claudia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_k9prgjblhva3g6rft2a7jipqf6