GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm

Genome-wide association studies (GWAS) yielded significant advances in defining the genetic architecture of complex traits and disease. Still, a major hurdle of GWAS is narrowing down multiple genetic associations to a few causal variants for functional studies. This becomes critical in multi-phenot...

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Detalles Bibliográficos
Autores principales: Bottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Zeller, Tanja, Liquet, Benoit, Newcombe, Paul, Yengo, Loic, Wild, Philipp S., Schillert, Arne, Ziegler, Andreas, Nielsen, Sune F., Butterworth, Adam S., Ho, Weang Kee, Castagné, Raphaële, Munzel, Thomas, Tregouet, David, Falchi, Mario, Cambien, François, Nordestgaard, Børge G., Fumeron, Fredéric, Tybjærg-Hansen, Anne, Froguel, Philippe, Danesh, John, Petretto, Enrico, Blankenberg, Stefan, Tiret, Laurence, Richardson, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738451/
https://www.ncbi.nlm.nih.gov/pubmed/23950726
http://dx.doi.org/10.1371/journal.pgen.1003657

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