Xanthine Oxidase Mediates Axonal and Myelin Loss in a Murine Model of Multiple Sclerosis

OBJECTIVES: Oxidative stress plays an important role in the pathogenesis of multiple sclerosis (MS). Though reactive oxygen species (ROS) are produced by various mechanisms, xanthine oxidase (XO) is a major enzyme generating ROS in the context of inflammation. The objectives of this study were to in...

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Detalles Bibliográficos
Autores principales: Honorat, Josephe Archie, Kinoshita, Makoto, Okuno, Tatsusada, Takata, Kazushiro, Koda, Toru, Tada, Satoru, Shirakura, Takashi, Fujimura, Harutoshi, Mochizuki, Hideki, Sakoda, Saburo, Nakatsuji, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738596/
https://www.ncbi.nlm.nih.gov/pubmed/23951137
http://dx.doi.org/10.1371/journal.pone.0071329

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