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Differential Response in Downstream Processing of CHO Cells Grown Under Mild Hypothermic Conditions

The manufacture of complex therapeutic proteins using mammalian cells is well established, with several strategies developed to improve productivity. The application of sustained mild hypothermic conditions during culture has been associated with increases in product titer and improved product quali...

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Detalles Bibliográficos
Autores principales:	Tait, Andrew S, Tarrant, Richard D R, Velez-Suberbie, M Lourdes, Spencer, Daniel I R, Bracewell, Daniel G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Bioseparations and Downstream Processing
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738919/ https://www.ncbi.nlm.nih.gov/pubmed/23636936 http://dx.doi.org/10.1002/btpr.1726

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