Role of Polycomb Proteins in Regulating HSV-1 Latency

Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and...

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Detalles Bibliográficos
Autores principales: Watson, Zachary, Dhummakupt, Adit, Messer, Harald, Phelan, Dane, Bloom, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738959/
https://www.ncbi.nlm.nih.gov/pubmed/23860385
http://dx.doi.org/10.3390/v5071740
Descripción
Sumario:Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.

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