Role of Polycomb Proteins in Regulating HSV-1 Latency

Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and...

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Detalles Bibliográficos
Autores principales: Watson, Zachary, Dhummakupt, Adit, Messer, Harald, Phelan, Dane, Bloom, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738959/
https://www.ncbi.nlm.nih.gov/pubmed/23860385
http://dx.doi.org/10.3390/v5071740
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author Watson, Zachary
Dhummakupt, Adit
Messer, Harald
Phelan, Dane
Bloom, David
author_facet Watson, Zachary
Dhummakupt, Adit
Messer, Harald
Phelan, Dane
Bloom, David
author_sort Watson, Zachary
collection PubMed
description Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition.
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spelling pubmed-37389592013-08-09 Role of Polycomb Proteins in Regulating HSV-1 Latency Watson, Zachary Dhummakupt, Adit Messer, Harald Phelan, Dane Bloom, David Viruses Review Herpes simplex virus (HSV) establishes a latent infection within sensory neurons of humans. Latency is characterized by the transcriptional repression of lytic genes by the condensation of lytic gene regions into heterochromatin. Recent data suggest that facultative heterochromatin predominates, and that cellular Polycomb proteins are involved in the establishment and maintenance of transcriptional repression during latency. This review summarizes these data and discusses the implication of viral and cellular factors in regulating heterochromatin composition. MDPI 2013-07-15 /pmc/articles/PMC3738959/ /pubmed/23860385 http://dx.doi.org/10.3390/v5071740 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Watson, Zachary
Dhummakupt, Adit
Messer, Harald
Phelan, Dane
Bloom, David
Role of Polycomb Proteins in Regulating HSV-1 Latency
title Role of Polycomb Proteins in Regulating HSV-1 Latency
title_full Role of Polycomb Proteins in Regulating HSV-1 Latency
title_fullStr Role of Polycomb Proteins in Regulating HSV-1 Latency
title_full_unstemmed Role of Polycomb Proteins in Regulating HSV-1 Latency
title_short Role of Polycomb Proteins in Regulating HSV-1 Latency
title_sort role of polycomb proteins in regulating hsv-1 latency
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738959/
https://www.ncbi.nlm.nih.gov/pubmed/23860385
http://dx.doi.org/10.3390/v5071740
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