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Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients

The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to th...

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Autores principales: Sabbagh, Zohreh, Markland, Janet, Vatanparast, Hassanali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738972/
https://www.ncbi.nlm.nih.gov/pubmed/23803739
http://dx.doi.org/10.3390/nu5072268
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author Sabbagh, Zohreh
Markland, Janet
Vatanparast, Hassanali
author_facet Sabbagh, Zohreh
Markland, Janet
Vatanparast, Hassanali
author_sort Sabbagh, Zohreh
collection PubMed
description The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to those with non-autoimmune diseases; further, to evaluate the impact of vitamin D on disease activity in rheumatoid arthritis (RA) cases. Methods: In a retrospective case-control study design, we evaluated 116 patients in a community clinic classified in two groups, Control group: patients with non-rheumatic disease (n = 56), and Case group: those with rheumatic diseases (n = 60). We compared plasma vitamin D status (25(OH)D), indicators of disease activity and other potential confounders. Further, we determined factors associated with disease activity in RA cases. Results: The plasma 25(OH)D was significantly lower in Case group (64.8 ± 29.8) compared to Control group (86.8 ± 37.7). High number of SARDs outpatients 56%) had considerably low plasma 25(OH)D concentration. RA cases with low plasma 25(OH)D had over five times higher risk of disease activity (OR = 5.15 95% CI 1.16, 22.9; p = 0.031). Conclusion: Inadequate vitamin D status in SARDs cases, along with considerably strong association with disease activity in RA cases, indicate the need for proper evaluation of vitamin D status in this clinical population. Moreover, appropriate training should be given to the patients to ensure the intake of the recommended amount of vitamin D per day through diet or supplement.
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spelling pubmed-37389722013-08-09 Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients Sabbagh, Zohreh Markland, Janet Vatanparast, Hassanali Nutrients Article The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to those with non-autoimmune diseases; further, to evaluate the impact of vitamin D on disease activity in rheumatoid arthritis (RA) cases. Methods: In a retrospective case-control study design, we evaluated 116 patients in a community clinic classified in two groups, Control group: patients with non-rheumatic disease (n = 56), and Case group: those with rheumatic diseases (n = 60). We compared plasma vitamin D status (25(OH)D), indicators of disease activity and other potential confounders. Further, we determined factors associated with disease activity in RA cases. Results: The plasma 25(OH)D was significantly lower in Case group (64.8 ± 29.8) compared to Control group (86.8 ± 37.7). High number of SARDs outpatients 56%) had considerably low plasma 25(OH)D concentration. RA cases with low plasma 25(OH)D had over five times higher risk of disease activity (OR = 5.15 95% CI 1.16, 22.9; p = 0.031). Conclusion: Inadequate vitamin D status in SARDs cases, along with considerably strong association with disease activity in RA cases, indicate the need for proper evaluation of vitamin D status in this clinical population. Moreover, appropriate training should be given to the patients to ensure the intake of the recommended amount of vitamin D per day through diet or supplement. MDPI 2013-06-26 /pmc/articles/PMC3738972/ /pubmed/23803739 http://dx.doi.org/10.3390/nu5072268 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Sabbagh, Zohreh
Markland, Janet
Vatanparast, Hassanali
Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
title Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
title_full Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
title_fullStr Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
title_full_unstemmed Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
title_short Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
title_sort vitamin d status is associated with disease activity among rheumatology outpatients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738972/
https://www.ncbi.nlm.nih.gov/pubmed/23803739
http://dx.doi.org/10.3390/nu5072268
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