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Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients
The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738972/ https://www.ncbi.nlm.nih.gov/pubmed/23803739 http://dx.doi.org/10.3390/nu5072268 |
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author | Sabbagh, Zohreh Markland, Janet Vatanparast, Hassanali |
author_facet | Sabbagh, Zohreh Markland, Janet Vatanparast, Hassanali |
author_sort | Sabbagh, Zohreh |
collection | PubMed |
description | The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to those with non-autoimmune diseases; further, to evaluate the impact of vitamin D on disease activity in rheumatoid arthritis (RA) cases. Methods: In a retrospective case-control study design, we evaluated 116 patients in a community clinic classified in two groups, Control group: patients with non-rheumatic disease (n = 56), and Case group: those with rheumatic diseases (n = 60). We compared plasma vitamin D status (25(OH)D), indicators of disease activity and other potential confounders. Further, we determined factors associated with disease activity in RA cases. Results: The plasma 25(OH)D was significantly lower in Case group (64.8 ± 29.8) compared to Control group (86.8 ± 37.7). High number of SARDs outpatients 56%) had considerably low plasma 25(OH)D concentration. RA cases with low plasma 25(OH)D had over five times higher risk of disease activity (OR = 5.15 95% CI 1.16, 22.9; p = 0.031). Conclusion: Inadequate vitamin D status in SARDs cases, along with considerably strong association with disease activity in RA cases, indicate the need for proper evaluation of vitamin D status in this clinical population. Moreover, appropriate training should be given to the patients to ensure the intake of the recommended amount of vitamin D per day through diet or supplement. |
format | Online Article Text |
id | pubmed-3738972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-37389722013-08-09 Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients Sabbagh, Zohreh Markland, Janet Vatanparast, Hassanali Nutrients Article The co-existence of high prevalence of vitamin D inadequacy among Canadians and high prevalence of systematic autoimmune rheumatic diseases (SARDs) raise the question on relationship between the two situations. Objective: To determine vitamin D status in known cases of common SARDs and compare to those with non-autoimmune diseases; further, to evaluate the impact of vitamin D on disease activity in rheumatoid arthritis (RA) cases. Methods: In a retrospective case-control study design, we evaluated 116 patients in a community clinic classified in two groups, Control group: patients with non-rheumatic disease (n = 56), and Case group: those with rheumatic diseases (n = 60). We compared plasma vitamin D status (25(OH)D), indicators of disease activity and other potential confounders. Further, we determined factors associated with disease activity in RA cases. Results: The plasma 25(OH)D was significantly lower in Case group (64.8 ± 29.8) compared to Control group (86.8 ± 37.7). High number of SARDs outpatients 56%) had considerably low plasma 25(OH)D concentration. RA cases with low plasma 25(OH)D had over five times higher risk of disease activity (OR = 5.15 95% CI 1.16, 22.9; p = 0.031). Conclusion: Inadequate vitamin D status in SARDs cases, along with considerably strong association with disease activity in RA cases, indicate the need for proper evaluation of vitamin D status in this clinical population. Moreover, appropriate training should be given to the patients to ensure the intake of the recommended amount of vitamin D per day through diet or supplement. MDPI 2013-06-26 /pmc/articles/PMC3738972/ /pubmed/23803739 http://dx.doi.org/10.3390/nu5072268 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Sabbagh, Zohreh Markland, Janet Vatanparast, Hassanali Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients |
title | Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients |
title_full | Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients |
title_fullStr | Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients |
title_full_unstemmed | Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients |
title_short | Vitamin D Status Is Associated with Disease Activity among Rheumatology Outpatients |
title_sort | vitamin d status is associated with disease activity among rheumatology outpatients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738972/ https://www.ncbi.nlm.nih.gov/pubmed/23803739 http://dx.doi.org/10.3390/nu5072268 |
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