Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

Meningiomas are the most common primary nervous system tumor. The tumor suppressor NF2 is disrupted in approximately half of meningiomas(1) but the complete spectrum of genetic changes remains undefined. We performed whole-genome or whole-exome sequencing on 17 meningiomas and focused sequencing on...

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Detalles Bibliográficos
Autores principales: Brastianos, Priscilla K., Horowitz, Peleg M., Santagata, Sandro, Jones, Robert T., McKenna, Aaron, Getz, Gad, Ligon, Keith L., Palescandolo, Emanuele, Van Hummelen, Paul, Ducar, Matthew D., Raza, Alina, Sunkavalli, Ashwini, MacConaill, Laura E., Stemmer-Rachamimov, Anat O., Louis, David N., Hahn, William C., Dunn, Ian F., Beroukhim, Rameen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739288/
https://www.ncbi.nlm.nih.gov/pubmed/23334667
http://dx.doi.org/10.1038/ng.2526

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