Fear and panic in humans with bilateral amygdala damage

Decades of research have highlighted the amygdala’s influential role in fear. Surprisingly, we found that inhalation of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amygdala damage. These results indicate that the amygdala is not required for fear and...

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Detalles Bibliográficos
Autores principales: Feinstein, Justin S., Buzza, Colin, Hurlemann, Rene, Follmer, Robin L., Dahdaleh, Nader S., Coryell, William H., Welsh, Michael J., Tranel, Daniel, Wemmie, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739474/
https://www.ncbi.nlm.nih.gov/pubmed/23377128
http://dx.doi.org/10.1038/nn.3323
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author Feinstein, Justin S.
Buzza, Colin
Hurlemann, Rene
Follmer, Robin L.
Dahdaleh, Nader S.
Coryell, William H.
Welsh, Michael J.
Tranel, Daniel
Wemmie, John A.
author_facet Feinstein, Justin S.
Buzza, Colin
Hurlemann, Rene
Follmer, Robin L.
Dahdaleh, Nader S.
Coryell, William H.
Welsh, Michael J.
Tranel, Daniel
Wemmie, John A.
author_sort Feinstein, Justin S.
collection PubMed
description Decades of research have highlighted the amygdala’s influential role in fear. Surprisingly, we found that inhalation of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amygdala damage. These results indicate that the amygdala is not required for fear and panic, and make an important distinction between fear triggered by external threats from the environment versus fear triggered internally by CO(2).
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spelling pubmed-37394742013-09-01 Fear and panic in humans with bilateral amygdala damage Feinstein, Justin S. Buzza, Colin Hurlemann, Rene Follmer, Robin L. Dahdaleh, Nader S. Coryell, William H. Welsh, Michael J. Tranel, Daniel Wemmie, John A. Nat Neurosci Article Decades of research have highlighted the amygdala’s influential role in fear. Surprisingly, we found that inhalation of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amygdala damage. These results indicate that the amygdala is not required for fear and panic, and make an important distinction between fear triggered by external threats from the environment versus fear triggered internally by CO(2). 2013-02-03 2013-03 /pmc/articles/PMC3739474/ /pubmed/23377128 http://dx.doi.org/10.1038/nn.3323 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Feinstein, Justin S.
Buzza, Colin
Hurlemann, Rene
Follmer, Robin L.
Dahdaleh, Nader S.
Coryell, William H.
Welsh, Michael J.
Tranel, Daniel
Wemmie, John A.
Fear and panic in humans with bilateral amygdala damage
title Fear and panic in humans with bilateral amygdala damage
title_full Fear and panic in humans with bilateral amygdala damage
title_fullStr Fear and panic in humans with bilateral amygdala damage
title_full_unstemmed Fear and panic in humans with bilateral amygdala damage
title_short Fear and panic in humans with bilateral amygdala damage
title_sort fear and panic in humans with bilateral amygdala damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739474/
https://www.ncbi.nlm.nih.gov/pubmed/23377128
http://dx.doi.org/10.1038/nn.3323
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