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Quantification of imatinib in human serum: validation of a high-performance liquid chromatography-mass spectrometry method for therapeutic drug monitoring and pharmacokinetic assays

BACKGROUND: Imatinib mesylate has been a breakthrough treatment for chronic myeloid leukemia. It has become the ideal tyrosine kinase inhibitor and the standard treatment for chronic-phase leukemia. Striking results have recently been reported, but intolerance to imatinib and noncompliance with trea...

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Detalles Bibliográficos
Autores principales:	Rezende, Vinicius Marcondes, Rivellis, Ariane, Novaes, Mafalda Megumi Yoshinaga, de Alencar Fisher Chamone, Dalton, Bendit, Israel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2013
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739544/ https://www.ncbi.nlm.nih.gov/pubmed/23946646 http://dx.doi.org/10.2147/DDDT.S42902

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