Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination

Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipie...

Descripción completa

Detalles Bibliográficos
Autores principales: Moss, Alastair J., Gaughran, Fiona P., Karasu, Aliyye, Gilbert, Anthony S., Mann, Alex J., Gelder, Colin M., Oxford, John S., Stephens, Henry A., Lambkin-Williams, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739771/
https://www.ncbi.nlm.nih.gov/pubmed/23951151
http://dx.doi.org/10.1371/journal.pone.0071376
_version_ 1782476953341657088
author Moss, Alastair J.
Gaughran, Fiona P.
Karasu, Aliyye
Gilbert, Anthony S.
Mann, Alex J.
Gelder, Colin M.
Oxford, John S.
Stephens, Henry A.
Lambkin-Williams, Rob
author_facet Moss, Alastair J.
Gaughran, Fiona P.
Karasu, Aliyye
Gilbert, Anthony S.
Mann, Alex J.
Gelder, Colin M.
Oxford, John S.
Stephens, Henry A.
Lambkin-Williams, Rob
author_sort Moss, Alastair J.
collection PubMed
description Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14–40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
format Online
Article
Text
id pubmed-3739771
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-37397712013-08-15 Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination Moss, Alastair J. Gaughran, Fiona P. Karasu, Aliyye Gilbert, Anthony S. Mann, Alex J. Gelder, Colin M. Oxford, John S. Stephens, Henry A. Lambkin-Williams, Rob PLoS One Research Article Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14–40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination. Public Library of Science 2013-08-09 /pmc/articles/PMC3739771/ /pubmed/23951151 http://dx.doi.org/10.1371/journal.pone.0071376 Text en © 2013 Moss et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Moss, Alastair J.
Gaughran, Fiona P.
Karasu, Aliyye
Gilbert, Anthony S.
Mann, Alex J.
Gelder, Colin M.
Oxford, John S.
Stephens, Henry A.
Lambkin-Williams, Rob
Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination
title Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination
title_full Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination
title_fullStr Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination
title_full_unstemmed Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination
title_short Correlation between Human Leukocyte Antigen Class II Alleles and HAI Titers Detected Post-Influenza Vaccination
title_sort correlation between human leukocyte antigen class ii alleles and hai titers detected post-influenza vaccination
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739771/
https://www.ncbi.nlm.nih.gov/pubmed/23951151
http://dx.doi.org/10.1371/journal.pone.0071376
work_keys_str_mv AT mossalastairj correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT gaughranfionap correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT karasualiyye correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT gilbertanthonys correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT mannalexj correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT geldercolinm correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT oxfordjohns correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT stephenshenrya correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination
AT lambkinwilliamsrob correlationbetweenhumanleukocyteantigenclassiiallelesandhaititersdetectedpostinfluenzavaccination

Ejemplares similares