The Interactions in the Carboxyl Terminus of Human 4-Hydroxyphenylpyruvate Dioxygenase Are Critical to Mediate the Conformation of the Final Helix and the Tail to Shield the Active Site for Catalysis

4-Hydroxylphenylpyruvate dioxygenase (4-HPPD) is an important enzyme for tyrosine catabolism, which catalyzes the conversion of 4-hydroxylphenylpyruvate (4-HPP) to homogentisate. In the present study, human 4-HPPD was cloned and expressed in E. coli. The kinetic parameters for 4-HPP conversion were:...

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Detalles Bibliográficos
Autores principales: Lin, Jang-Foung, Sheih, Yung-Lin, Chang, Tsu-Chung, Chang, Ni-Yuan, Chang, Chiung-Wen, Shen, Chia-Pei, Lee, Hwei-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739788/
https://www.ncbi.nlm.nih.gov/pubmed/23950902
http://dx.doi.org/10.1371/journal.pone.0069733

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