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Acetaminophen Attenuates Doxorubicin-Induced Cardiac Fibrosis Via Osteopontin and GATA4 Regulation: Reduction of Oxidant Levels
It is well documented in animal and human studies that therapy with the anti-cancer drug doxorubicin (DOX) induces fibrosis, cardiac dysfunction, and cell death. The most widely accepted mechanism of cardiac injury is through production of reactive oxygen species (ROS), which cause mitochondrial dam...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739938/ https://www.ncbi.nlm.nih.gov/pubmed/23526585 http://dx.doi.org/10.1002/jcp.24367 |