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Somatic Alpha-Synuclein Mutations in Parkinson's Disease: Hypothesis and Preliminary Data

Alpha-synuclein (SNCA) is crucial in the pathogenesis of Parkinson's disease (PD), yet mutations in the SNCA gene are rare. Evidence for somatic genetic variation in normal humans, also involving the brain, is increasing, but its role in disease is unknown. Somatic SNCA mutations, arising in ea...

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Detalles Bibliográficos
Autores principales:	Proukakis, Christos, Houlden, Henry, Schapira, Anthony H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Viewpoint
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739940/ https://www.ncbi.nlm.nih.gov/pubmed/23674490 http://dx.doi.org/10.1002/mds.25502

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