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Backpropagating Action Potentials Enable Detection of Extrasynaptic Glutamate by NMDA Receptors

Synaptic NMDA receptors (NMDARs) are crucial for neural coding and plasticity. However, little is known about the adaptive function of extrasynaptic NMDARs occurring mainly on dendritic shafts. Here, we find that in CA1 pyramidal neurons, backpropagating action potentials (bAPs) recruit shaft NMDARs...

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Detalles Bibliográficos
Autores principales:	Wu, Yu-Wei, Grebenyuk, Sergei, McHugh, Thomas J., Rusakov, Dmitri A., Semyanov, Alexey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740263/ https://www.ncbi.nlm.nih.gov/pubmed/22832274 http://dx.doi.org/10.1016/j.celrep.2012.03.007

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