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Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling

Acid ceramidase (AC) is overexpressed in most prostate tumors and confers oncogenic phenotypes to prostate cancer cells. AC modulates the cellular balance between ceramide, sphingosine and sphingosine 1-phosphate (S1P). These bioactive sphingolipids have diverse, powerful and often oppositional impa...

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Detalles Bibliográficos
Autores principales:	Beckham, T H, Cheng, J C, Lu, P, Shao, Y, Troyer, D, Lance, R, Marrison, S T, Norris, J S, Liu, X
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740300/ https://www.ncbi.nlm.nih.gov/pubmed/23732709 http://dx.doi.org/10.1038/oncsis.2013.14

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