Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst

This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows th...

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Detalles Bibliográficos
Autores principales: Rossy, Cybille, Fouquet, Eric, Felpin, François-Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740569/
https://www.ncbi.nlm.nih.gov/pubmed/23946838
http://dx.doi.org/10.3762/bjoc.9.160
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author Rossy, Cybille
Fouquet, Eric
Felpin, François-Xavier
author_facet Rossy, Cybille
Fouquet, Eric
Felpin, François-Xavier
author_sort Rossy, Cybille
collection PubMed
description This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups.
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spelling pubmed-37405692013-08-14 Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst Rossy, Cybille Fouquet, Eric Felpin, François-Xavier Beilstein J Org Chem Letter This paper describes the preparation of indoles, azaindoles and benzofurans in pure water by using a new heterogeneous Pd–Cu/C catalyst through a cascade Sonogashira alkynylation–cyclization sequence. Details of the optimization studies and the substrate scope are discussed. This procedure allows the preparation of heterocycles with good yields and is tolerant to a wide variety of functional groups. Beilstein-Institut 2013-07-16 /pmc/articles/PMC3740569/ /pubmed/23946838 http://dx.doi.org/10.3762/bjoc.9.160 Text en Copyright © 2013, Rossy et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Rossy, Cybille
Fouquet, Eric
Felpin, François-Xavier
Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_full Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_fullStr Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_full_unstemmed Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_short Practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
title_sort practical synthesis of indoles and benzofurans in water using a heterogeneous bimetallic catalyst
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740569/
https://www.ncbi.nlm.nih.gov/pubmed/23946838
http://dx.doi.org/10.3762/bjoc.9.160
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