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Total synthesis of ochnaflavone
The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Beilstein-Institut
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740604/ https://www.ncbi.nlm.nih.gov/pubmed/23946830 http://dx.doi.org/10.3762/bjoc.9.152 |
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author | Ndoile, Monica M van Heerden, Fanie R |
author_facet | Ndoile, Monica M van Heerden, Fanie R |
author_sort | Ndoile, Monica M |
collection | PubMed |
description | The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental conditions for the oxidative cyclization to form ochnaflavone were established. |
format | Online Article Text |
id | pubmed-3740604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Beilstein-Institut |
record_format | MEDLINE/PubMed |
spelling | pubmed-37406042013-08-14 Total synthesis of ochnaflavone Ndoile, Monica M van Heerden, Fanie R Beilstein J Org Chem Full Research Paper The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental conditions for the oxidative cyclization to form ochnaflavone were established. Beilstein-Institut 2013-07-08 /pmc/articles/PMC3740604/ /pubmed/23946830 http://dx.doi.org/10.3762/bjoc.9.152 Text en Copyright © 2013, Ndoile and van Heerden https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
spellingShingle | Full Research Paper Ndoile, Monica M van Heerden, Fanie R Total synthesis of ochnaflavone |
title | Total synthesis of ochnaflavone |
title_full | Total synthesis of ochnaflavone |
title_fullStr | Total synthesis of ochnaflavone |
title_full_unstemmed | Total synthesis of ochnaflavone |
title_short | Total synthesis of ochnaflavone |
title_sort | total synthesis of ochnaflavone |
topic | Full Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740604/ https://www.ncbi.nlm.nih.gov/pubmed/23946830 http://dx.doi.org/10.3762/bjoc.9.152 |
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