Lanostane- and cycloartane-type triterpenoids from Abies balsamea oleoresin

Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and compariso...

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Detalles Bibliográficos
Autores principales: Lavoie, Serge, Gauthier, Charles, Legault, Jean, Mercier, Sylvain, Mshvildadze, Vakhtang, Pichette, André
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2013
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740800/
https://www.ncbi.nlm.nih.gov/pubmed/23946828
http://dx.doi.org/10.3762/bjoc.9.150
Descripción
Sumario:Phytochemical analysis of A. balsamea oleoresin led to the isolation of three new 3,4-seco-lanostane triterpenoids 1–3, one new cycloartane triterpenoid 4 along with fourteen known terpenoids. Structure determinations were based on extensive 1D/2D NMR, IR and MS spectroscopic analyses, and comparison with literature data. The isolated compounds were evaluated in vitro for their cytotoxicity against human cell lines (A549, DLD-1, WS1) and their antibacterial activity against E. coli and S. aureus. Abiesonic acid (6) exhibited weak cytotoxic activity against A549 (IC(50) = 22 µM) while compounds 1 and 4 were weakly active against S. aureus (MIC = 25 µM).

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